Production of 1,4-dihydropyridinecarboxylic acids

Details Production of 1,4-dihydropyridinecarboxylic acids Production of 1,4-dihydropyridinecarboxylic acids

1981-01-19

1984-11-20

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

546321, 546257, 546258, 546167, 546144, 546281, 546193, 546194, 544238, 544333, 544405, 544284, 544353, 544365, 2602444, C07D27910, C07D21322, C07D21702, C07D21168

Patent

active

044839855

ABSTRACT:
The invention relates to a process for the production of 1,4-dihydropyridinecarboxylic acid compounds which involves hydrolysis, under alkaline conditions and in a temperature range from 10.degree. to 100.degree. C., of an ester group which contains an electron-attracting group. The invention also includes novel compounds made according to the invention as well as compositions containing said novel compounds. Also included in the invention are methods for the use of said compounds and compositions. The compounds obtained according to the process of the invention are useful because of their circulation-influencing action and are also useful as intermediates for the preparation of compounds having circulation-influencing action.

REFERENCES:
Noller, Textbook of Organic Chemistry, 2nd Edition, W. B. Saunders Company, Philadelphia, 1958.

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