Method and use of IL-1.alpha.

Details Method and use of IL-1.alpha. Method and use of IL-1.alpha.

1994-06-01

1996-08-06

Walsh, Stephen G.

Drug, bio-affecting and body treating compositions

Lymphokine

Interleukin

4242781, A61K 3820

Patent

active

055431402

ABSTRACT:
Methods for stimulating immunity, inhibiting tumor growth, promoting production of a cytokine, and preventing or inhibiting radiation injury by administration of Interleukin-1.alpha. (IL-1.alpha.) derivatives, are disclosed.

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patent: 5376639 (1994-12-01), Yamada et al.
Sato et al "Recombinant Interleukin 1 Alpha and Beta Stimulate . . . "Biochem. Biophys. Res. Comm. 141 (1):285-291 (Nov. 1986).
Onozaki et al, "Human Interleukin 1 is a Cytocidal Factor For Several Tumor Cell Lines", J. Immunol. 135(6):3962-3968 (Dec. 1985).
Nakamura et al, "Antitumor Effect of Recombinant Human Interleukin 1 Alpha Against Murine Syngeneic Tumors", Jpn. J. Cancer Res. 77: 767-773 (Aug. 1986).
Chu et al, "Role of Interleukin 1 in Antigen-Specific T Cell Proliferation"J. Immunol. 132(3):1311-1316 (Mar. 1984).
March et al, "Cloning, Sequence and Expression of Two Distinct Human Interleukin-1 Complementary DNAs", Nature, 315(6021):641-647 (1985).
Wells et al, "Cassette Mutagenesis: An Efficient Method for Generation of Multiple Mutations at Defined Sites", Gene, 34:315-323 (1985).

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