Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Testing efficacy or toxicity of a compound or composition
Patent
1994-08-05
1996-08-06
Campell, Bruce R.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Testing efficacy or toxicity of a compound or composition
435948, 435974, 800 2, 800DIG5, A61K 4900
Patent
active
055431313
ABSTRACT:
Strains of HIV-2 capable of infecting humans and non-human primates such as baboons and causing an immune system disease are disclosed. The HIV-2 strain are used to infect non-human primates which infected primates present symptoms of a disease of the immune system and are used to test drugs, e.g., anti-virals and/or vaccines for their ability to treat and/or prevent lentiviral infections such as HIV infections. Useful strains are HIV-2.sub.UC2, HIV-2.sub.UC12 and HIV-2.sub.UC14 and preferred non-human primates are baboons.
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Bozicevic Karl
Campell Bruce R.
The Regents of the University of California
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