Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-05-18
1996-06-25
Gibson, Sharon
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548253, A61K 3141, C07D25700
Patent
active
055300162
ABSTRACT:
Novel substituted 2,4-imidazolidinediones are prepared either by reaction of .alpha.-aminocarboxylic acid derivatives with appropriately substituted biphenylmethyl halides and subsequent cyclization with isocyanates or by reaction of N-benzyl-substituted .alpha.-aminocarboxylic acid derivatives with tetrazolylphenylboronic acids or by reaction of sulphonyl-substituted benzyl halides with .alpha.-aminocarboxylic acid derivatives and subsequent cyclization with isocyanates. The compounds according to the invention can be employed as active compounds in medicaments, preferably for the treatment of arterial hypertension and arteriosclerosis.
REFERENCES:
CA 85: 194264 1976.
CA 74: 75896 1970.
JP 52/100 469 (Feb. 20, 1976).
JP 52/140 470 (May 11, 1976).
The Journal of Cell Biology, vol. 50, 1971, pp. 172-186.
Chemical Abstracts, vol. 88, No. 7, 13 Feb. 1978, abstract No. 50859z, p. 549.
Beuck Martin
Bischoff Hilmar
Denzer Dirk
Dressel Jurgen
Fey Peter
Bayer Aktiengesellschaft
Gibson Sharon
Scalzo Catherine
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