Stabilization and purification of interferon with propylene glyc

Details Stabilization and purification of interferon with propylene glyc Stabilization and purification of interferon with propylene glyc

1983-01-07

1984-11-20

Hazel, Blondel

Drug, bio-affecting and body treating compositions

Lymphokine

260112R, A61K 4502, C07G 700

Patent

active

044838492

ABSTRACT:
A new process for stabilizing purified human interferon is described, using propylene glycol. Propylene glycol also aids in the interferon purification procedure. Older methods used stabilizing agents which are toxic, antigenic or irritating. The new process will make available significantly more interferon of clinical purity for use in patients with cancer, viral illnesses and other diseases as yet undesignated (e.g. multiple sclerosis, amyotropic lateral sclerosis, scleroderma, etc.).

REFERENCES:
Sedmak, J. et al., Methods in Enzymology, vol. 78, pp. 591-593, Academic Press, 1981.
Merck Index, p. 1017, 9th edition, 1976.

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