Sulfated glycosaminoglycanoid derivatives of the dermatan sulfat

Details Sulfated glycosaminoglycanoid derivatives of the dermatan sulfat Sulfated glycosaminoglycanoid derivatives of the dermatan sulfat

1994-11-02

1996-06-25

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 54, 514 61, 536118, 536119, 536120, 536122, A61K 31715, C08B 3700, C07H 510, C07H 1302

Patent

active

055299857

ABSTRACT:
The invention relates to sulfated glycosaminoglycanoid derivatives of the dermatan sulfate and chondroitin sulfate type, of which N-sulfate, N-acetate, and hydroxy groups, are replaced by alkoxy, aryloxy, aralkoxy, or O-sulfate groups. The compounds have antithrombotic and smooth muscle cell proliferation inhibiting activities.

REFERENCES:
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patent: 4818816 (1989-04-01), Petitiou et al.
patent: 4841041 (1989-06-01), van Boeckel et al.
patent: 5380716 (1995-01-01), Conrad et al.
L. F. Tietze et al., "Proton-mediated Liberation of Aldophosphamide from a Nontoxic Prodrug: A Strategy for Tumor-selective Activation of Cytocidal Drugs," Cancer Research, vol. 49, pp. 4179-4184, Aug. 1, 1989.

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