Small molecule inhibition of RNA/ligand binding

Details Small molecule inhibition of RNA/ligand binding Small molecule inhibition of RNA/ligand binding

1995-06-07

1997-09-16

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5142322, 514316, 514333, 514422, 514471, 514438, 514343, 514336, 5142355, 514141, 514326, 514211, 544111, 544129, 546208, 546256, 546187, 5462804, 5462834, 548527, 5483154, 5483131, 548518, 549 74, 549491, 540544, 540596, A61K 31415, C07D23364

Patent

active

056681658

ABSTRACT:
Disclosed is a method for the inhibition of binding of a ligand to an RNA, the inhibition being mediated by a small organic molecule that binds to the RNA, thereby inhibiting ligand binding. A preferred class of small organic molecules are compounds exemplified by 2,5-Bis[3-(2-N,N-dimethylaminopropylamidino)phenyl]furan.

REFERENCES:
patent: 4619942 (1986-10-01), Tidwell et al.
patent: 4933347 (1990-06-01), Tidwell et al.
patent: 5463071 (1995-10-01), Himmelbach et al.
Wilson, W.D. et al Biochemistry 1993, 32(!5), pp. 4098-4104.
Anne, J. et al Antimicrob. Agents Chemother. 1980, 18(2), pp. 231-239.
Jiang, Z. et al Macromolecules 1992, 25(2), pp. 880-882.
Boykin, J. Med. Chem., 20:531, (1977).
Bartel et al., Cell, 67:529, (1991).
CDC, MMWR, 35 [20]: 334-339, (1986).
Daly et al., Biochem. 32:10497, (1993).
Dann et al., Liebigs Ann. Chem., 160 (1975).
Greenidge et al., Mol. Pharmacol. 43:982, (1993).
Harding, R. D., Trans. R. Soc. Trop Med. Hyg., 39:99-124, (1945).
Hope et al., Proc. National Acad. Sci, USA, 87:7787-7791, (1990).
Malim et al., Nature 338:254, (1989).
Michael et al., J. Virol., 65:1291-1303, (1991).
Napier et al., Indian Med. Gaz., 78:177-183, (1943).
Pomerantz et al., Cell, 61:1271-1276, (1990).
Stern et al., Genes & Development, 5:2555-2566, (1991).
Von Ahsen et al., J. Mol. Biol., 226:935-41 (1992).
Merck Index [Neamine, amikacin, sisomycin, ribostamycin, butirosin, Kananycin B, Kanamycin A, tobramycin, gentamycin, neomycin B, paromomycin 1, lividomycin A, and hygromycin B] 1939.
Uwe von Ahsen et al., "Non-competitive Inhibition of Group I Intron RNA Self-splicing by Aminoglycoside Antibiotics", J. Mol. Biol., 226:935-941 (1992).
Michael H. Malim et al., "Functional Dissection of the HIV-1 Rev Trans-Activator-Derivation of a Trans-Dominant Repressor of Rev Function", Cell, vol. 58, pp. 205-214, (1989).
Roger J. Pomerantz et al., "Cells Nonproductively Infected with HIV-1 Exhibit an Aberrant Pattern of Viral RNA Expression: A Molecular Model For Latency", Cell, vol. 61, pp. 1271-1276, (1990).
David P. Bartel et al., "HIV-1 Rev Regulation Involves Recognition of Nion-Watson-Crick Base Pairs in Viral RNA", Cell, vol. 67, pp. 529-536, (1991).
Seth Stern et al., "The Herpes simplex virus trans-activator VP16 recognizes the Oct-1 homeo domain: evidence for a homeo domain recognition subdomain", Genes & Development vol. 5, pp. 2555-2566, (1991).
Nelson L. Michael et al., "Induction of Human Immunodeficiency Virus Type 1 Expression in Chronically Infected Cells is Associated Primarily with a Shift in RNA Splicing Patterns", Journal of Virology, 65, pp. 1291-1303, (1991).
Otto Dann et al., "Trypanocide Diamidine mit drei isolierten Ringsystemen", Liebigs Ann. Chem, pp. 160-194, (1975).
Bijan P. Das et al., "Synthesis and Antiprotozoal Activity of 2,5-Bis(4-guanylphenyl)furans", Journal of Med. Chemistry, vol. 20, No. 4, pp. 531-536, (1977).
Paulette A. Greenidge et al., "DNA Minor Groove Recognition Properties of Pentamidine and its Analogs: A Molecular Modeling Study", Molecular Pharmacology, vol. 43, pp. 982-988 (1993).
Constance A. Bell et al., "Structure-Activity Relationships of Pentamidine Analogs against Giardia Lamblia and Correlation of Antigiardial Activity with DNA-Binding Affinity", Antimicrobial Agents and Chemotherapy, 35, pp. 1099-1107, (1991).
David W. Boykin et al., "Dicatiionic Diarylfurans as Anti-Pneumocystis carinii Agents", J. Med. Chem., vol. 38, pp. 912-916, (1995).
W. David Wilson et al., "The Search for Structure-Specific Nucleic Acid-Interactive Drugs: Effects of Compound Structure on RNA versus DNA Interaction Strength", Biochemistry, vol. 32, pp. 4098-4104, (1993).

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