Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1996-07-09
1997-09-16
Gerstl, Robert
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514312, 514326, 514370, 546209, 5462704, 546256, 548193, 548194, 548201, 548203, 548205, C07D27726, A61K 31425
Patent
active
056681615
ABSTRACT:
A class of substituted thiazolyl compounds is described for use in treating inflammation disorders. Compounds are defined by Formula II ##STR1## wherein R.sup.1 is selected from hydrido, alkyl, haloalkyl, cyanoalkyl, alkylamino, aralkyl, arylamino, heteroarylsulfonylalkyl, heteroarylsulfonylhaloalkyl, aralkylamino, aryloxyalkyl, alkoxycarbonyl, aryl optionally substituted at a substitutable position with one or more radicals selected from halo and alkoxy, and heterocyclic optionally substituted at a substitutable position with one or more radicals selected from halo and alkyl; wherein R.sup.4 is selected from alkyl and amino; and wherein R.sup.5 is selected from aryl and heteroaryl; wherein R.sup.5 is optionally substituted at a substitutable position with one or more radicals selected from halo, alkyl and alkoxy; provided R.sup.5 is not phenyl at position 4 when R.sup.1 is .alpha.,.alpha.-bis(trifluoromethyl)methanol and R.sup.4 is methyl; or a pharmaceutically-acceptable salt thereof.
REFERENCES:
patent: 4346088 (1982-08-01), Lang
patent: 4632930 (1986-12-01), Carizi
patent: 5550142 (1996-08-01), Ducharme et al.
Yagupolskii Zh.okh. 31 (4/1315, (1961).
Carter Jeffery S.
Collins Paul W.
Kramer Steven W.
Penning Thomas D.
Rogers Roland S.
Bulock Joseph W.
G.D. Searle & Co.
Gerstl Robert
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