Symmetrical bis-heteroarylmethoxyphenyliminoxyalkyl carboxylates

Details Symmetrical bis-heteroarylmethoxyphenyliminoxyalkyl carboxylates Symmetrical bis-heteroarylmethoxyphenyliminoxyalkyl carboxylates

1996-09-17

1997-09-16

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514357, 546174, 546335, A61K 3147, A61K 3144, C07D21514, C07D21330

Patent

active

056681461

ABSTRACT:
Compounds having the formula: ##STR1## or a pharmaceutically acceptable salt thereof wherein W and Y at each occurrence are the same and W is selected from the group consisting of optionally substituted quinolyl, optionally substituted benzothiazolyl, optionally substituted benzoxazolyl, optionally substituted benzimidazolyl, optionally substituted quinoxalyl, optionally substituted pyridyl, optionally substituted pyrimidyl, and optionally substituted thiazolyl; Y is selected from optionally substituted phenylene and optionally substituted ##STR2## wherein the alkylene portion is of one to six carbon atoms; A is selected from alkylene, alkenylene, cycloalkylene, and optionally substituted ##STR3## wherein the alkylene portion is of one to six carbon atoms; and M is selected from hydrogen, a pharmaceutically acceptable cation, a pharmaceutically acceptable, metabolically cleavable group, --OR.sup.3, and --NR.sup.4 R.sup.5, inhibit leukotriene biosynthesis and are useful in the treatment of allergic and inflammatory disease states. Also disclosed are leukotriene biosynthesis inhibiting compositions and a method of inhibiting leukotriene biosynthesis in a mammal.

REFERENCES:
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Musser et al., J. Med. Chem 1992, 35, 2501-2524.
Prasit et al; Bioorganic and Medicinal Chemistry Letters 1(11) 645-648 (1991).

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