Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1996-05-31
1997-09-16
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514255, 514303, 514307, 514314, 514318, 514338, 544124, 544360, 546118, 546148, 546164, 546165, 546193, 5462737, C07D40112, C07D40114, A61K 31415, A61K 3144
Patent
active
056681313
DESCRIPTION:
BRIEF SUMMARY
This application is a 371 of PCT/EP94/03911 filed on Nov. 26, 1994.
AREA OF APPLICATION OF THE INVENTION
The invention relates to compounds which are intended to be used in the pharmaceutical industry as active substance for the production of pharmaceuticals.
KNOWN TECHNICAL BACKGROUND
International Patent Application WO92/12976 describes 2-(pyridylmethylthio- and -sulfinyl)benzimidazoles which are substituted in a particular manner and which are said to be active against helicobacter bacteria, and for which it is furthermore disclosed that they are intended to be suitable for preventing and treating a whole range of gastric disorders.
DESCRIPTION OF THE INVENTION
The invention relates to compounds of formula I (see appended sheet of formulae) in which or predominantly fluorine-substituted 1-4C-alkoxy, chlorodifluoromethoxy or 2-chloro-1,1,2-trifluoroethoxy, substituted by R7, R8 and R9, both are bonded, an unsubstituted or substituted heterocyclic ring which is selected from the group consisting of pyrrolidine, piperidine, piperazine, morpholine, indoline, octahydro-1H-indole, 1,2,3,4-tetrahydroquinoline, 1,2,3,4-tetrahydroisoquinoline, decahydroquinoline and decahydroisoquinoline, where different substituents selected from the group consisting of identical or different substituents selected from the group consisting of 6 by a 1-4C-alkyl radical and is substituted in position 4 by a substituent selected from the group consisting of different 1-4C-alkyl radicals, by a carboxyl group or by one or two identical or different 1-4C-alkyl radicals, and can be substituted in the benzo moiety by one or two identical or different substituents selected from the group consisting of 1-4C-alkyl, halogen and nitro, two identical or different substituents selected from the group consisting of 1-4C-alkyl and halogen, positions 1, 3 and/or 4 by one or two identical or different substituents selected from the group consisting of 1-4C-alkyl, carboxyl, phenyl, phenyl-1-4C-alkyl or phenyl which is substituted by R7, R8 and R9 in the phenyl radical, and can be substituted on the benzo moiety by one or two substituents selected from the group consisting of hydroxyl, 1-4C-alkoxy and di-1-4C-alkylamino, and where 1-4C-alkylamino or nitro,
1-4C-Alkyl stands for straight-chain or branched alkyl radicals with 1 to 4 carbon atoms. Examples which may be mentioned are the butyl, isobutyl, sec-butyl, tert-butyl, propyl, isopropyl, ethyl and methyl radicals.
1-4C-Alkoxy stands for a radical which, besides the oxygen atom, contains one of the abovementioned 1-4C-alkyl radicals. Examples which may be mentioned are the methoxy and ethoxy radicals.
Halogen for the purpose of the present invention is bromine, chlorine and fluorine.
Examples of wholly or predominantly fluorine-substituted 1-4C-alkoxy which may be mentioned are the 1,2,2-trifluoroethoxy, the 2,2,3,3,3-pentafluoropropoxy, the perfluoroethoxy and, in particular, the 1,1,2,2-tetrafluoroethoxy, the trifluoromethoxy, the 2,2,2-trifluoroethoxy and the difluoromethoxy radicals.
1-7C-Alkyl stands for straight-chain and branched alkyl radicals with 1 to 7 carbon atoms. Examples which may be mentioned are the heptyl, hexyl, neopentyl, isopentyl, pentyl, butyl, isobutyl, sec-butyl, tert-butyl, propyl, isopropyl, ethyl and methyl radicals.
1-7C-Alkylene stands for straight-chain or branched 1-7C-alkylene radical, for example the methylene (--CH.sub.2 --), ethylene (--CH.sub.2 --CH.sub.2 --), trimethylene (--CH.sub.2 --CH.sub.2 --CH.sub.2 --), tetramethylene (--CH.sub.2 --CH.sub.2 --CH.sub.2 --CH.sub.2), 1,2-dimethylethylene [--CH(CH.sub.3)--], 1,1-dimethylethylene [--C(CH.sub.3).sub.2 --CH.sub.2 --], 2,2-dimethylethylene --CH.sub.2 --C(CH.sub.3).sub.2 --], isopropylidene [--C(CH.sub.3).sub.2 --], 1-methylethylene [--CH(CH.sub.3)CH.sub.2 --], pentamethylene (--CH.sub.2 --CH.sub.2 --CH.sub.2 --CH.sub.2 --CH.sub.2 --), hexamethylene (--CH.sub.2 --CH.sub.2 --CH.sub.2 --CH.sub.2 --CH.sub.2 --CH.sub.2 --) and heptamethylene radicals (--CH.sub.2 --CH.sub.2 --CH.sub.2 --CH.sub.2 --CH.sub.2
ByK Gulden Lomberg Chemische Fabrik GmbH
Rao Deepak
Shah Mukund J.
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