5-Oxy-substituted derivatives of Psoralene useful in dermatology

Details 5-Oxy-substituted derivatives of Psoralene useful in dermatology 5-Oxy-substituted derivatives of Psoralene useful in dermatology

1977-05-26

1980-08-12

Jiles, Henry R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

26034321, 549 71, 424203, 424180, 424275, 424279, C07H 1706, C07D49304

Patent

active

042174457

ABSTRACT:
An improved process for obtaining 5-methoxy-psoralene from bergamot oil, a method for preparing the compound 5-hydroxy-psoralene from 5-methoxy-psoralene and a method of making novel psoralene derivatives by replacing the hydrogen atom of the 5-hydroxy group with an R group are disclosed. These compounds are prepared by reacting the 5-hydroxy-psoralene with a halide RX in the presence of sodium hydride. Compounds of particular interest are those of which the radical R is: alkanoyl of not more than 10 carbon atoms; orthoacetoxy-benzoyl; .alpha.thenoyl; O,O diethyl-phosphono; diethylaminoethyl, and 2'3'4'6' tetra .alpha. acetyl D-gluco pyranosyl.

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