Peptide conjugate

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Insulin; related peptides

Patent

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Details

530304, 530345, 530399, 530394, 530409, A61K 3514, A61K 3800, A61K 3828, A61K 700, C07K 700

Patent

active

054420431

ABSTRACT:
The present invention provides a conjugate capable of passing the blood-brain barrier comprising a bioactive peptide or protein incapable of passing the blood-brain barrier and a carrier peptide which exhibits substantially no bioactivity and which is capable of passing the blood-brain barrier. The conjugate makes it possible to allow a bioactive peptide or protein incapable of passing the blood-brain barrier to easily pass the blood-brain barrier for uniform transport to the brain without any side effect of the carrier peptide.

REFERENCES:
patent: 4801575 (1989-01-01), Pardridge
Pardridge, W. M. (1992) Pharmacol. Toxicol. 7, 3-10 Recent Developments in Peptide Drug Delivery to the Brain.

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