Compositions containing aqueous dispersions of lipid spheres

Drug – bio-affecting and body treating compositions – Topical sun or radiation screening – or tanning preparations – Aromatic acid or derivative containing

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252316, 252522A, 424 19, 424 31, 424 32, 424 36, 424 38, 424 59, 424 62, 424 63, 424280, 426 89, A61K 744, A61K 7021

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active

042173442

ABSTRACT:
The present invention relates to a process for producing a dispersion of spheres comprising arranged molecular layers encapsulating an aqueous phase. The process comprises admixing a water-dispersible lipid component with the aqueous phase to be encapsulated, the liphophile/hydrophile ratio of the lipid component being such that the lipid swells in the said aqueous phase so as to form a lamellar phase. The lamellar phase is agitated and there is added thereto a dispersion liquid in an amount greater than the resulting lamellar phase and the resulting mixture is vigorously agitated for a period of time ranging from 15 minutes to 3-4 hours. The spheres can encapsulate a water-soluble pharmaceutical, a cosmetic or a food and the dispersions containing said encapsulated materials can be used particularly in the pharmaceutical and cosmetic fields.

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patent: 3957971 (1976-05-01), Oleniacz
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Tanford: The Hydrophobic Effect: Formation of Micelles and Biological Membranes, a Wiley-Interscience Publ., (1973), pp. 78-79.
Ruckenstein et al.: "Thermodynamics of Amphiphilar Aggregation into Micelles and _Vesicles", Micellization, Solubilization, and Microemulsions, vol. 1, Mittal, Plenum Press, (1976), pp. 133-149.
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