Sustained-release preparation

Details Sustained-release preparation Sustained-release preparation

1995-06-06

1997-09-16

Schain, Howard B.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

424 7808, 424 7833, 525415, 528354, A61K 3800, C08G 6308

Patent

active

056681119

ABSTRACT:
A sustained-release preparation which comprises a physiologically active peptide of general formula ##STR1## wherein X represents an acyl group; R.sub.1, R.sub.2 and R.sub.4 each represents an aromatic cyclic group; R.sub.3 represents a D-amino acid residue or a group of the formula ##STR2## wherein R.sub.3 ' is a heterocyclic group; R.sub.5 represents a group of the formula --(CH.sub.2).sub.n --R.sub.5 ' wherein n is 2 or 3, and R.sub.5 ' is an amino group which may optionally be substituted, an aromatic cyclic group or an O-glycosyl group;

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patent: 5036047 (1991-07-01), Mia
patent: 5110904 (1992-05-01), Haviv et al.
patent: 5140009 (1992-08-01), Haviv et al.
patent: 5171835 (1992-12-01), Janaky et al.
patent: 5187150 (1993-02-01), Speiser et al.
patent: 5480868 (1996-01-01), Kamei et al.
Hutchinson et al., Trends in Biotech 5(4): 102 (1987).

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