Dipeptide chromogenic substrates

Details Dipeptide chromogenic substrates Dipeptide chromogenic substrates

1979-03-23

1980-08-12

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424177, C07C10352, C07G 700

Patent

active

042172691

ABSTRACT:
The present invention comprises compounds of the formula ##STR1## and the biologically acceptable acid addition salts thereof, wherein R.sub.1 represents an alkylene having 2-4 carbon atoms; R.sub.2 is selected from the group consisting of amino and quanyl; R.sub.3 is selected from the group consisting of nitrophenyl, methylnitrophenyl, dinitrophenyl, naphthyl and nitronaphthyl; X represents halo or lower alkyl having 1-4 carbon atoms; and n is 3 or 4. The compounds of the present invention are analytical reagents useful for measuring proteolytic enzymes such as thrombin and trypsin. The enzymatic hydrolysis of the invention compounds provides a chromogenic amine by which the proteolytic enzyme concentration can be determined spectrophotometrically.

REFERENCES:
patent: 3884896 (1975-05-01), Blomback et al.
patent: 4016042 (1977-04-01), Svendsen
patent: 4061625 (1977-12-01), Ekenstam et al.
patent: 4070245 (1978-01-01), Svendsen

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