Polypeptides that potentiate bactericidal/permeability-increasin

Details Polypeptides that potentiate bactericidal/permeability-increasin Polypeptides that potentiate bactericidal/permeability-increasin

1993-02-26

1996-02-06

Wax, Robert A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 73, 435 696, 530324, 536 231, 536 232, 536 235, C12P 2106, C07H 1900, C07H 2100, A61K 3800

Patent

active

054896762

ABSTRACT:
Disclosed herein are purified isolated mammals polypeptides having the property of potentiating the bacterial growth inhibitory activity of bactericidal/permeability-increasing protein and pharmaceutical formulations comprising these polypeptides. Also disclosed is a method for obtaining mammalian polypeptides having the property of potentiating the bacterial growth inhibitory activity of bactericidal/permeability-increasing protein potentiating activity, and methods for treating gram-negative bacterial infections in mammals and for neutralizing lipopolysaccharides. Also disclosed is a method for the treatment of diseases caused by endotoxins in mammals.

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