Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Animal cell – per se – expressing immunoglobulin – antibody – or...
Patent
1995-05-10
1997-09-16
Feisee, Lila
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Animal cell, per se, expressing immunoglobulin, antibody, or...
4353201, 536 2353, 536 234, 53038823, 5303917, 5303913, C07H 2104, C12N 1513, C12N 1585, C07K 1618
Patent
active
056680031
ABSTRACT:
The invention relates to nucelic acids encoding monoclonal antibodies to human leukemia inhibitory factor. The disclosed monoclonal antibodies are believed to recognize unique epitopes on hLIF and are useful in the treatment of conditions wherein the presence of hLIF causes or contributes to undesirable pathological effects, such as cachexia, dysregulated calcium metabolism, or excessive bone cell proliferation, and in the detection of hLIF, for example, in clinical samples or specimens.
REFERENCES:
patent: 4722899 (1988-02-01), Hamaoka et al.
patent: 5045451 (1991-09-01), Uhr et al.
patent: 5106951 (1992-04-01), Morgan, Jr. et al.
Abe etal., "Differentiation-Inducing Factor Purified From Conditioned Medium of Mitogen-Treated Spleen Cell Cultures Stimulated Bone Resorption" Proc. Natl. Acad. Sci. USA 83:5958-5962 (1986).
Allan et al., "Osteoblasts Display Receptors for and Responses to Leukemia-Inhibitory Factor" J. Cellular Physiology 145:110-119 (1990).
Baumann et al., "Hepatocyte-Stimulating Factor III Shares Structural and Functional Identity with Leukemia-Inhibitory Factor" J. Immonul. 143:1163-1167 (1989).
Borrebaeck, Carl A.K., "Strategy for the production of human monoclonal antibodies using in vitro activated B cells" J. Immunol. Methods 123:157-165 (1989).
Davies, Tony, "Magic Bullets" Nature 289:12-13 (1981).
Ferrara et al., "Pituitary Follicular Cells Secrete and Inhibitor of Aortic Endothelial Cell Growth: Identification as Leukemia Inhibitory Factor" Proc. Natl. Acad. Sci. USA 89:698-702 (1992).
Gearing et al., "Molecular Cloning and Expression of cDNA Encoding a Murine Myeloid Leukaemia Inhibitory Factor (LIF)" The EMBO Journal 6(13):3995-4002 (1987).
Gough et al., "Molecular Cloning and Expresion of the Human Homologue of the Murine Gene Encoding Myeloid Leukemia-Inhibitory Factor" Proc. Natl. Acad. Sci. USA 85:2623-2627 (1988).
Harris et al., "Therapeutic antibodies--the coming of age" TIBTECH 11;42-44 (Feb. 1993).
Hilton et al., "Leukemia Inhibitory Factor: A Biological Perspective" J. Cell Biochem. 46:21-26 (1991).
Hilton et al., "Specific Binding of Murine Leukemia Inhibitory Factor to Normal and Leukemic Monocytic Cells" Proc. Natl. Acad. Sci. USA 85:5971-5975 (1988).
Maekawa et al., "Clonal Suppression of HL60 and U937 Cells by Recombinant Human Leukemia Inhibitory Factor in Combination with GM-CSF or G-CSF" Leukemia 3(4):270-276 (1989).
Mori et al., "Purification of a Lipoprotein Lipase-Inhibiting Protein Produced by a Melanoma Cell Line Associated with Cancer Cachexia" Biochem. & Biophys. Res. Comm. 160(3):1085-1092 (1989).
Murphy et al., "Generation of Sensory Neurons is Stimulated by Leukemia Inhibitory Factor" Proc. Natl. Acad. Sci. USA 88:3498-3501 (1991).
Reid et al., "Leukemia Inhibitory Factor: A Novel Bone-Active Cytokine" Endocrin. 126(3):1416-1420 (1990).
Rose et al., "Oncostatin M is a Member of a Cytokine Family That Includes Leukemia-Inhibitory Factor, Granulocyte Colony-Stimulating Factor, and Interleukin 6" Proc. Natl. Acad. Sci. USA 88:8641-8645 (1991).
Seaver, "Monoclonal Antibodies in Industry: More Difficult Than Originally Thought" Genetic Engineering NewsAug. 1994:10 and 21 (1994).
Tomida et al., "Characterization of a Factor Inducing Differentiation of Mouse Myeloid Leukemic Cells Purified from Conditioned Medium of Mouse Ehrlich Ascites Tumor Cells" FEBS Letts 178(2) :291-296 (1984).
Tomida et al., "Preparation and Neutralization Characteristics of an Antibody to the Factor Inducing Differentiation of Mouse Myeloid Leukemic Cells" FEBS Letts 151(2) :281-285 (1983).
Tomida et al., "Purification of a Factor Inducing Differentiation of Mouse Myeloid Leukemic M1 Cells from Conditioned Medium of Mouse Fibroblast L929 Cells." Journal of Biological Chemistry 259(17) :10978-10982 (1984).
Waldemann, T., "Monoclonal antibodies in diagnosis and therapy" Science 252:1657-1662 (1991).
Yamamori et al., "The Cholinergic Neuronal Differentiation Factor from Heart Cells is Identical to Leukemia Inhibitory Factor" Science 246:1412-1416 (1989).
Sevier et al, Clinical Chemistry 27: 1797-1806, 1981.
Morrison, Science 229: 1202-1207, 1985.
Huston et al, PNAS 85: 5879-5883, 1985.
Better et al, Methods Enzymology 178:476-496, 1989.
Vitetta et al, Science 238: 1098-1104, 1987.
Alphonso et al., J. Leukocyte Biology Suppl. 2:1-15 p. 49 Abstract #124, 1991.
Conley Deirdre L.
Feisee Lila
Genentech Inc.
Johnson Nancy A.
Torchia Timothy E.
LandOfFree
Nucleic acid encoding monoclonal antibodies to leukemia inhibito does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Nucleic acid encoding monoclonal antibodies to leukemia inhibito, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nucleic acid encoding monoclonal antibodies to leukemia inhibito will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-217590