2-pyridylacetic acid derivatives, pharmaceutical composition con

Details 2-pyridylacetic acid derivatives, pharmaceutical composition con 2-pyridylacetic acid derivatives, pharmaceutical composition con

1986-10-31

1988-04-19

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514318, 514336, 514343, 546193, 546194, 546268, 546281, 546331, C07D21383, A61K 3144

Patent

active

047389770

ABSTRACT:
A 2-pyridylacetic acid derivative having the formula (I): ##STR1## wherein R.sup.1 represents an alkyl having 1 to 15 carbon atoms, an alkenyl having 5 to 20 carbon atoms or an aralkyl having 7 to 15 carbon atoms; R.sup.2 represents hydrogen, a linear or cyclic alkyl, a hydroxyalkyl group, an alkenyl, an aryl, an aralkyl or a group--(CH.sub.2)--A, where n represents an integer of 0 to 3 and A represents a nitrogen-containing heterocyclic group which may be substituted with an alkyl having 1 to 10 carbon atoms or an aralkyl having 7 to 10 carbon atoms and a pharmacologically acceptable acid addition salt thereof.
This compound has both effects of the inhibition of gastric acid and the protection of gastric mucosa, which is low in toxicity.
Accordingly, it is useful as a therapeutical agent for peptic ulcer disease.

REFERENCES:
patent: 4272534 (1981-06-01), Aloup
Smith, The Chemistry of Open-Chain Organic Nitrogen Compounds, vol. I, p. 29, Benjamin Pub. 1965.
March, Advanced Organic Chemistry, Reactions, Mechanisms and Structure, Second Edition, p. 386, McGraw-Hill Pub. 1977.

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