Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1979-09-27
1981-11-24
Wiseman, Thomas G.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 29, 435241, C12Q 168, C12Q 129, C12N 502
Patent
active
043025358
ABSTRACT:
An assay is disclosed for determining mutagenic damage caused by the administration of a known or suspected mutagen to diploid human lymphoblastoid cell lines. The gene locus employed for this assay is the gene for thymidine kinase, uridine kinase, or cytidine deaminase. Since human lymphoblastoid cells contain two genes for these enzymes, heterozygotes of human lymphoblastoid cells are used in this assay.
REFERENCES:
patent: 4066510 (1978-01-01), Thilly
Clive, "A Linear Relationship Between Tumorigenic Potency in Vivo and Mutagenic Potency at the Heterozygous Thymidine Kinase (TK.sup.+/-) locus of L5178 Mouse Lymphoma Cells Coupled with Mammalian Metabolism", Chem. Abstracts, vol. 89, No. 3 (1978), p. 163, Abs. No. 18129w.
Trosko et al., "Sensitive Method to Measure Physical and Chemical Carcinogen induced unscheduled DNA Synthesis in rapidly dividing eukaryotic cells", Chem. Abstracts, vol 81, No. 25, (1974), Abs. No. 165808c.
Marquart et al., "Induction of Malignant Transformation and Mutagenesis in Cell Cultures by Cancer Chemotherapeutic Agents", vol. 40, No. 4, (1977), pp. 1930-1934.
Hoppe, IV Henry
Liber Howard L.
Penman Bruce W.
Skopek Thomas R.
Thilly William G.
Brook David E.
Massachusetts Institute of Technology
Smith, Jr. Arthur A.
Wiseman Thomas G.
LandOfFree
Assay for mutagenesis in heterozygous diploid human lymphoblasts does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Assay for mutagenesis in heterozygous diploid human lymphoblasts, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Assay for mutagenesis in heterozygous diploid human lymphoblasts will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2175411