Sulfated ligands for l-selectin and methods of treating inflamma

Details Sulfated ligands for l-selectin and methods of treating inflamma Sulfated ligands for l-selectin and methods of treating inflamma

1996-05-02

1996-02-06

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 25, 514 53, 514 54, 514 62, 536 41, 536 172, 536 187, 536 53, 536 54, 536 551, 536 552, 536 55, A61K 3720, A61K 3170, A61K 3702, A61K 3900

Patent

active

054895782

ABSTRACT:
Sulfated oligosaccharides which bind to L-selectin receptors and act as agonists are formulated into pharmaceutical formulations and administered by injection to treat inflammation. Compounds which act as metabolic inhibitors of carbohydrate sulfation and inhibit the sulfation of naturally occurring ligands for L-selectin receptors are administered locally by injection to alleviate and/or prevent inflammation. The sulfated oligosaccharides can be administered in combination with the chlorates and sulfatases in order to obtain a combined effect which is useful in preventing and/or alleviating inflammation. A preferred group of ligands are obtained by the hydrolysis of GlyCAM-1 by separation procedures including high pH anion exchange chromatography. The invention describes compounds that have the recognition determinants for L-selectin on GlyCAM-1 as Galactose-6-sulfate and/or N-acetylglucosamine-6-sulfate, in concert with sialic acid and fucose.

REFERENCES:
patent: 5143712 (1992-09-01), Brandley et al.
Green et al., Biochem. Biophys. Res. Commun. 1992, 188(1), 244-251.
Suzuki et al., Biochem. Biophys. Res. Commun. 1993, 190(2), 426-434.
Needham et al., Proc. Nat. Acad. Sci. 1993, 90, 1359-1363.
Mawhinney et al., Carbohydr Res. 1992, 235, 179-197.
Capon et al., Eur. J. Biochem. 1989, 182, 139-152.

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