Polypeptide-diesters, their production and use

Details Polypeptide-diesters, their production and use Polypeptide-diesters, their production and use

1983-07-13

1985-12-17

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 15, 514 16, 514 17, 2601125R, C07C10352, A61K 3702

Patent

active

045593248

ABSTRACT:
Novel polypeptide-diesters, inclusive of salts thereof, which have the formula: ##STR1## wherein A.sub.1 is arginine or lysine or a di- or tripeptide residue having arginine or lysine at its N-terminal; A.sub.2 is an aromatic amino acid residue; A.sub.3 is a neutral amino acid or aromatic amino acid residue; each of the amino acid residues mentioned may be optionally L-configured or D-configured; and n is 0, 1 or 2. These compounds are useful as analgesics.

REFERENCES:
patent: 4218474 (1980-08-01), Barnish et al.

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