Methods for producing antibody libraries using universal or rand

Details Methods for producing antibody libraries using universal or rand Methods for producing antibody libraries using universal or rand

1994-09-02

1997-09-16

Eisenschenk, Frank C.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 7021, 435 711, 5303873, C07K 1600, C12N 1500

Patent

active

056679882

ABSTRACT:
The present invention describes methods for producing antibody libraries, and particularly for increasing antibody library diversity by inducing mutagenesis within the CDR regions of immunoglobulin heavy or light chains that are displayed on the surface of filamentous phage particles comprising the library. The invention also describes oligonucleotides useful for increasing the library diversity, and universal light chains useful in the library production methods.

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