Monoclonal antibodies to prostate cells

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435 79, 43524027, 436 64, 436813, 424 149, 5303879, 5303888, 53038885, 5303897, G01N 3353, G01N 33574

Patent

active

054895251

ABSTRACT:
Monoclonal antibodies are provided which bind to an antigen associated with prostate cells, including prostate cancers. The monoclonal antibodies and recombinant forms thereof are used individually or conjugated radioisotopes to target the compounds to cancerous prostate cells, and thus are useful in a variety of diagnostic procedures.

REFERENCES:
patent: 4444744 (1984-04-01), Goldenberg
patent: 4970299 (1990-11-01), Bazinet et al.
patent: 5055404 (1991-10-01), Udea et al.
Starling, et al., Cancer Res., vol. 46, pp. 367-374, Jan. 1986.
Monoclonal Antibody Technology, A. M. Campbell, Elsevier, New York, pp. 98-100, 1987.
Lowe, D. H., et al., J. Urol. 132(4) pp. 780-785, "A Human Monoclonal Antibody Reactive with Human Prostate" 1984.
Brinkman et al., "A Recombinant Immunotoxin that is Active on Prostate Cancer Cells and that is Composed of the Fv Region of Monoclonal Antibody PR1 and a Truncated Form of Pseudomonas Exotoxin" Proc. Natl. Acad. Sci. USA 90:547-551 (Jan., 1993).
Pastan et al., "PR1--A Monoclonal Antibody That Reacts With an Antigen of the Surface of Normal and Malignant Prostate Cells", J. Nat'l. Can. Inst. 85(14):1149-1154 (Jul. 21, 1993).
Sablitzky et al., "Molecular Basis of an Isogeneic Anti-Idiotypic Response", EMBO J. 3: 3005-3012 (1984).
Starling et al., "Disulfide Bonding of a Human Prostate Tumor-associated Membrane Antigen Recognized by Monoclonal Antibody D83.21", Cancer Res. 45:804-808 (Feb., 1985).
Peehl, "Serial Culture of Adult Human Prostatic Epithelial Cells", J. Tiss. Cult. Meths. 9:53-60 (1985).
Peehl et al., "Serum-Free Growth of Adult Human Prostatic Epithelial Cells", In Vitro 22:82-90 (Feb., 1986).
Horoszewicz et al., "Monoclonal Antibodies to a New Antigenic Marker in Epithelial Prostatic Cells and Serum of Prostatic Cancer Patients", Anticancer Res. 7: 927-936 (1987).
Kim et al., "Monoclonal Antibody PR92 with Restricted Specificity for Tumor-associated Antigen of Prostate and Breast Carcinoma", Cancer Res. 48:4543-4548 (Aug. 15, 1988).
Bazinet et al., "Immunohistochemical Characterization of Two Monoclonal Antibodies, P25,48 and P25.91, Which Define a New Prostate-specific Antigen", Cancer Res. 48:6938-6942 (Dec. 1988).
Lee et al., "Experimental Immunochemotherapy of Human Prostate Tumor with 5-Fluorodeoxyuridine Monoclonal Anti-Prostate Acid Phosphatase Antibody Conjugate", J. Tumor Marker Oncol. 3: 361-372 (1988).
De Boer "Symmetric Idiotypic Networks: Connectance & Switching, Stability, and Suppression", Theoretical Immunology, Pt. Two, A. S. Perelson, ed., pp. 265-289 (1988) Addison Wesley Pub. Co.
Lopes et al., "Immunohistochemical and Pharmacokinetic Characterization of the Site-specific Immunoconjugate CYT-356 Derived from Antiprostate Monoclonal Antibody 7E11-C5", Cancer Res. 50:6423-6429 (Oct. 1, 1990).
Wright et al., "Radiolocalization of Human Prostate Tumor in a Mouse Subrenal Capsule Model by Monoclonal Antibody TURP-27", The Prostate 16: 81-89 (1990).
Beckett et al. "Monoclonal Antibody PD41 Recognizes an Antigen Restricted to Prostate Adenocarcinomas", Cancer Res. 51:1326-1333 (Feb. 15, 1991).
Lipford et al., "Comparative Study of Monoclonal Antibodies TURP-27 and HNK-1: Their Relationship to Neural Cell Adhesion Molecules and Prostate Tumor-associated Antigens", Cancer Res. 51: 2296-2301 (May 1, 1991).
Pastan et al., "Characterization of Monoclonal Antibodies B1 & B3 that React with Mucinous Adenocarcinomas", Cancer Res. 51:3784-3787 (Jul. 15, 1991).
Tjota et al., "Murine Monoclonal Antibodies Reactive with a Variety of Androgen Independent Dunning Rat Prostate Adenocarcinoma Sublines Also Reactive with Human Prostate Adenocarcinoma", J. Urol. 146: 205-212 (Jul., 1991).
Brinkmann et al., "B3(Fv)-PE38KDEL, a Single-Chain Immunotoxin that Causes Complete Regression of a Human Carcinoma in Mice," Proc. Natl. Acad. Sci. USA 88:8616-8620 (Oct., 1991).
Gansow, "Newer Approaches to the Radiolabeling of Monoclonal Antibodies by Use of Metal Chelates", Int. J. Rad Appl. Instrum. [B], Nucl. Med. Biol. 18:369-381 (1991).
Peehl et al. "Culture of Prostatic Epithelial Cells from Ultrasound-Guided Needle Biopsies", The Prostate 19:141-147 (1991).
Wright et al., "A Novel Prostate Carcinoma-associated Glycoprotein Complex (PAC) Recognized by Monoclonal Antibody TURP-27", Int. J. Cancer 47: 717-725 (1991).
Brinkmann et al., "Independent Domain Folding of Pseudomonas Exotoxin & Single-Chain Immunotoxins: Influence of Interdomain Connections" Proc. Natl. Acad. Sci. USA 89:3075-3079 (Apr. 1992).
Chang et al., "Isolation and Characterization of a Monoclonal Antibody, K1, Reactive with Ovarian Cancers and Normal Mesothelium" Int. J. Cancer 50: 373-381 (1992).
Chang et al., "Frequent Expression of the Tumor Antigen CAK1 in Squamous-cell Carcinomas" Int. J. Cancer 51: 548-554 (1992).
Chang et al., "Monoclonal Antibody K1 Reacts with Epithelia Mesothelioma But Not With Lung Adenocarcinoma", Amer J. Surg. Pathol. 16: 258-268 (1992).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Monoclonal antibodies to prostate cells does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Monoclonal antibodies to prostate cells, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Monoclonal antibodies to prostate cells will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2174592

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.