8.beta.,12.alpha.-17-Phenyl-18,19,20 trinor PGF.sub.2.sub..beta.

Details 8.beta.,12.alpha.-17-Phenyl-18,19,20 trinor PGF.sub.2.sub..beta. 8.beta.,12.alpha.-17-Phenyl-18,19,20 trinor PGF.sub.2.sub..beta.

1974-10-29

1976-09-07

Killos, Paul J.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260520B, 424308, C07C 6522, C07C 6514

Patent

active

039794393

ABSTRACT:
This invention is a group of 8-beta, 12-alpha-PG.sub.2 (prostaglandin-type) analogs having variable chain length, or methyl or phenyl substitution in the hydroxy-substituted side-chain, and processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, and labor inducement at term.

REFERENCES:
patent: 3862984 (1975-01-01), Pike et al.
Corey et al., J. Org. Chem., 37, 3043 (1972).
Gandolf, et al., Tet. Letters 4303 (1972).

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