Rate-controlled drug release system

Details Rate-controlled drug release system Rate-controlled drug release system

1984-08-09

1985-12-17

Metz, Andrew H.

Surgery

Controlled release therapeutic device or system

Osmotic or diffusion pumped device or system

424 19, 424 21, 424DIG7, 204192R, A61M 3100

Patent

active

045590540

ABSTRACT:
A drug release device employing a block copolymer of poly(ether-urethane)/poly(dimethyl siloxane) is useful for dispensing lipophilic drugs at a high controlled rate for prolonged periods of time. The initial "burst effect" of drug release experienced with prior drug release devices is eliminated or at least substantially reduced with these devices.

REFERENCES:
patent: 3948254 (1976-04-01), Zaffaroni
patent: 3993072 (1976-11-01), Zaffaroni
patent: 4215691 (1980-08-01), Wong
patent: 4235988 (1980-11-01), Fildes
patent: 4377010 (1983-03-01), Fydelor et al.

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