Method of treatment or inhibition of tumors using pyridyl-substi

Details Method of treatment or inhibition of tumors using pyridyl-substi Method of treatment or inhibition of tumors using pyridyl-substi

1999-08-18

2000-12-12

Krass, Frederick

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

428601, 428608, A61K 31675

Patent

active

061599573

ABSTRACT:
A method of treatment or inhibition of tumors involves administering a compound to a subject. The compound is one in which one or more of the eight phenyl substituents in the compound [M(dppe).sub.2 ].sup.+, in which M is selected from Au(I), Ag(I) and Cu(I), is substituted by 2, 3, or 4 pyridyl substituents. The compound has anti-tumor activity and an octanol/water partition coefficient between 0.01 and 25.5. The compound has selective toxicity to cancer cells, including cisplatin resistant human carcinoma cells lines.

REFERENCES:
patent: 4902675 (1990-02-01), Hill et al.

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