Preparation of 1,2-dihydro-6-(lower alkyl)-2-oxo-5-(pyridinyl)ni

Details Preparation of 1,2-dihydro-6-(lower alkyl)-2-oxo-5-(pyridinyl)ni Preparation of 1,2-dihydro-6-(lower alkyl)-2-oxo-5-(pyridinyl)ni

1982-05-24

1983-11-01

Jiles, Henry R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D21364

Patent

active

044131275

ABSTRACT:
The invention resides in a process for preparing cardiotonically active 1,2-dihydro-6-(lower-alkyl)-2-oxo-5-(pyridinyl)nicotinonitriles (III) which comprises reacting a pyridinylmethyl lower-alkyl ketone (I) with tri-(lower-alkyl) orthoformate, acetic anhydride and acetic acid to produce 2-(lower-alkoxy)-1-(pyridinyl)ethenyl lower-alkyl ketone (II) and then reacting II with malononitrile in a lower-alkanol, where pyridinyl is 4- or 3-pyridinyl or 4- or 3-pyridinyl having one or two lower-alkyl substituents.

REFERENCES:
patent: 2824121 (1958-02-01), Nicholl et al.
patent: 4223149 (1980-09-01), Opalka, Jr. et al.
patent: 4276293 (1981-06-01), Lesher et al.
patent: 4313951 (1982-02-01), Lesher et al.
Mezheritskii et al., Russian Chemical Reviews 42 (5), 392, 399-402 and 410 (1973).

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