7-[2-[(Substituted benzoyl]amino]acetamido]cephalosporins

Details 7-[2-[(Substituted benzoyl]amino]acetamido]cephalosporins 7-[2-[(Substituted benzoyl]amino]acetamido]cephalosporins

1978-12-07

1982-07-06

Coughlan, Jr., Paul M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

544 23, 544 25, 544 28, 544 29, 544 30, C07D50142

Patent

active

043384390

ABSTRACT:
Cephalosporin antibiotics of the formula ##STR1## wherein R is cyclohexadienyl, phenyl or substituted phenyl, 2-thienyl, 3-thienyl, 2-furyl or 3-furyl; R.sub.1 is a substituted phenyl having 1 to 4 hydroxy substituents or 1 to 3 amino substituents; and wherein Q is halo, methoxy, methyl or a group of the formula --CH.sub.2 R.sub.2 wherein R.sub.2 is alkanoyloxy, carbamoyloxy, alkoxy, halo, pyridinium or substituted pyridinium or a group of the formula --SR.sub.3 wherein R.sub.3 is alkyl, phenyl, substituted phenyl or a 5 or 6 membered-heteroaryl group having from 1 to 4 heteroatoms selected from the group consisting of O, S, and N;
are highly active broad spectrum antibiotics especially useful in the treatment of infections attributable to the gram-negative microorganisms.

REFERENCES:
patent: 3982011 (1976-09-01), Schmidt et al.

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