Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1987-08-07
1989-01-03
Hollrah, Glennon H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548253, C07D25704, A61K 3141
Patent
active
047957549
ABSTRACT:
A new compound, 3-(1H-tetrazol-5-yl)oxanilic acid and pharmaceutically acceptable salts thereof are herein disclosed, which can be prepared by reacting 3-(1H-tetrazol-5-yl)aniline with a compound represented by the general formula: A--CO--CO--B (wherein A and B may be identical with or different from one another and represent hydroxyl group, a halogen atom or a lower alkoxy group) and then optionally hydrolyzing the resultant product. The compound presents an excellent histamine and SRS-A release inhibitory effect and is hydrophilic or soluble in water. Therefore, the compound is very suitable to form, in particular, an aqueous pharmaceuticals for treatment or prevention of allergic diseases such as bronchial asthma, rhinitis and conjunctivitis.
REFERENCES:
patent: 4400381 (1983-08-01), Favier et al.
patent: 4432986 (1984-02-01), Erickson
patent: 4442115 (1984-04-01), Ramsden et al.
patent: 4443460 (1984-04-01), Rodrigez et al.
"Procedures for immunochemical study of histamine release from leukocytes with small volume of blood", Charles D. May, M. D., et al., J. Allerg., vol. 46, No. 1, pp. 12-20 (Jul., 1970).
"Antiallergic Properties of an Orally Effective Agent, [[3-(1H-Tetrazol-5-yl)Phenyl]Amino] Oxoacetic Acid n-Butyl Ester", Mitsuji Agata, et al., Japan. J. Pharmacol., 32, 689-697 (1982).
Abe Tooru
Hashimoto Terumasa
Horio Yoshihiro
Ootake Yasuhiro
Sawaki Shohei
Hollrah Glennon H.
Springer D. B.
Wakamoto Pharmaceutical Co., Ltd.
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