Pyridoxine derivatives and related pharmaceutical compositions

Details Pyridoxine derivatives and related pharmaceutical compositions Pyridoxine derivatives and related pharmaceutical compositions

1981-10-20

1983-11-01

Ford, John M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424263, 546116, 546273, 546302, A61K 31435, C07D401112, C07D21367

Patent

active

044129963

ABSTRACT:
The esters of pyridoxine and of isopropylidene pyridoxine with 1-(p-chlorobenzoyl)-2-methyl-5-methoxy-indol-3-acetic acid and 5-(2,4-difluorophenyl)-salicylic acid are essentially endowed with the same activities of the corresponding acids and are less toxic and gastrolesive, whereby the therapeutical index is remarkably improved. For the preparation of these compounds the chloride of the acid is reacted with isopropylidene pyridoxine, followed by a hydrolysis to obtain the corresponding pyridoxine derivative.

REFERENCES:
patent: 4165428 (1979-08-01), Noda et al.
patent: 4233304 (1980-11-01), Reiner
Merck Index, (1976) p. 4840.

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