Process for preparing 16.alpha.-hydroxy-17.alpha.-aminopregnane

Details Process for preparing 16.alpha.-hydroxy-17.alpha.-aminopregnane Process for preparing 16.alpha.-hydroxy-17.alpha.-aminopregnane

1981-11-18

1983-11-01

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26039745, 26039747, C07J 4300

Patent

active

044129530

ABSTRACT:
A process for preparing 16.alpha.-hydroxy-17.alpha.-aminopregnane derivatives through the opening of the corresponding 16.alpha., 17.alpha.-epoxides with amines.
The use of the thus obtained compounds as intermediates in the synthesis of pharmacologically active pregnano-[17.alpha.,16.alpha.-d]oxazolines is also claimed.

REFERENCES:
patent: 3631033 (1971-12-01), Nathansohn et al.
patent: 4031075 (1977-06-01), Woods et al.
A. I. Terekhina et al., Khim. Farm. Zur, 11, pp. 97-100, (1977), Also Included is a Copy of the Corresponding Derwent Abstract (13005v).
A. A. Akhrem et al., Bull., Acad., Pol. Sci., vol. XII, pp. 929-933, (1974).
G. G. Nathansohn et al., Gazz. Chim., Ital. 95, pp. 1338-1370, (1965).

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