Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector
Patent
1980-02-26
1981-07-14
Shaver, Paul F.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
556422, C07F 710, A61K 31725, A01N 5500, A61K 31695
Patent
active
042786665
ABSTRACT:
The invention provides a novel class of organosilicon compounds and a method for the preparation thereof as well as an anti-tumor agent containing the compound having very remarkable anti-tumor activity but with very low toxicity. The inventive compound is a (trihydrocarbylsilylmethyloxyimino)alkane, which is a silicon-containing oxime compound hitherto not described in any prior art literatures, represented by the general formula R.sup.1.sub.3 Si--CH.sub.2 --O--N.dbd.Y, R.sup.1 is a substituted or unsubstituted monovalent hydrocarbon group having from 1 to 10 carbon atoms and Y is a divalent hydrocarbon group denoted by .dbd.CR.sup.2 R.sup.3 or .dbd.CR.sup.4, R.sup.2 and R.sup.3, which may be identical or different, having the same meaning as R.sup.1 defined above and R.sup.4 being an alkylene group to form a ring structure jointly with the carbon atom directly bonded to the nitrogen atom. Typical examples of the compounds are: 2-(trimethylsilylmethyloxyimino) butane, 2-(trimethylsilylmethyloxyimino)propane, 2-(dimethylphenylsilylmethyloxyimino) butane and trimethylsilylmethyloxyiminocyclohexane.
REFERENCES:
patent: 3592795 (1971-07-01), Ashby
patent: 3697568 (1972-10-01), Boissieras et al.
patent: 3826782 (1974-07-01), Lengnick
patent: 4033991 (1977-07-01), Shinohara et al.
patent: 4126630 (1978-11-01), Muller et al.
Ito Koichi
Sato Ryuichi
Shinohara Toshio
Toyoshima Shigeshi
Yamamoto Yasushi
Shaver Paul F.
Shin-Etsu Chemical Co. , Ltd.
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