Process and apparatus for the production of sterile filtered blo

Details Process and apparatus for the production of sterile filtered blo Process and apparatus for the production of sterile filtered blo

1979-03-30

1981-07-14

Schain, Howard E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

210927, 424101, 424177, 23230B, 422 44, 210774, 210782, A61K 3516, A61K 3702, C07G 700

Patent

active

042785928

ABSTRACT:
A process and apparatus for the manufacture of sterile filtered blood clotting factore from fibrinogen with an enrichment of Factor I is provided. The process includes the step of extracting blood from at least one donor, manufacturing fibrinogen from the blood extracted in a known manner, dissolving the fibrinogen in a buffer, and effecting a sterile filtration of the buffer-dissolved fibrinogen by means of a static filtration device at a pressure of less than 0.5 atmospheres.

REFERENCES:
patent: 4141887 (1979-02-01), Seufert
Cohn et al., J. Am. Chem. Soc. 68, pp. 459-475, (1946).
Bove, Transfusion 18, pp. 129-136, (1978).
Grade et al., J. Am. Med. Association 220, pp. 692-701 (1972).
Rossev L. Mainwaring et al., J. Am. Med. Assoc. 195, pp. 143-147, (1966).
Holzbach et al., Ohio State Med. J. 67, pp. 327-332, (1971).
Roberts, New England J. of Med. 284, p. 218, (1971).
Rodriguez-Erdmann, New England J. of Med. 284, pp. 1039-1040, (1971).
Sise, J. of Reproductive Med. 10, pp. 115-117, (1973).

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