Prostaglandins

Details Prostaglandins Prostaglandins

1982-09-30

1984-02-07

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

560 15, 560 17, 560 35, 560120, 562427, 562440, 562502, 260404, 564 91, 546342, 424277, 424308, 424317, C07C13102, A61K 3119, C07C13108

Patent

active

044303459

ABSTRACT:
Novel bicyclo [2,2,1] heptanes and hept-2Z-enes are substituted at the 5-position by a 6-carboxyhex-2-enyl group or a modification thereof, and at the 6-position by an aldoxime or ketoxime group which is O-substituted by an aliphatic hydrocarbon residue, an aromatic residue, or an aliphatic hydrocarbon residue substituted directly or through an oxygen or sulphur atom by an aromatic residue. Such compounds may be prepared by the action of an oximating agent on an intermediate which is substituted at the 6-position by an aldehydic or ketonic carbonyl group. The compounds are of value for use in pharmaceutical compositions particularly in the context of the inhibition of thromboxane activity.

REFERENCES:
patent: 3946065 (1976-03-01), Matsui
patent: 4073933 (1978-02-01), Shimomura

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