Stabilization of PGI.sub.2 compounds with surfactants

Details Stabilization of PGI.sub.2 compounds with surfactants Stabilization of PGI.sub.2 compounds with surfactants

1978-07-17

1984-02-07

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

Bacterium or component thereof or substance produced by said...

A61K 3134

Patent

active

044303408

ABSTRACT:
The present invention provides novel methods for the stabilization of aqueous solutions of prostacyclin and related prostacyclin analogs comprising the addition of neutral or cationic surfactants to such aqueous solutions. Additionally, the novel surfactant-containing solutions of prostacyclin and related compounds are described. Finally there are provided novel pharmaceutical compositions comprising surfactant-containing aqueous solutions of prostacyclin and related compounds.

REFERENCES:
patent: 3851052 (1974-11-01), Monkhouse
patent: 3882241 (1975-05-01), Pharriss
patent: 3899587 (1975-08-01), Pharriss
patent: 3903297 (1975-09-01), Robert
Moncada et al., Nature, vol. 263, Oct. 21, 1976, pp. 663-665.

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