Method for detecting enzymes capable of digesting fibrinogen or

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1951035R, 195127, G01N 3114

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active

040466353

ABSTRACT:
A method for detecting and measuring the activity of enzymes capable of digesting fibrinogen or fibrin and for detecting and measuring the activity of enzyme activators and enzyme inhibitors of said enzymes, by incubating an unknown enzyme sample in a humid labelled fibrinogen or labelled fibrin coated test apparatus, isolating the labelled degradation products of fibrinogen or fibrin released by the unknown enzyme sample and measuring the labelled degradation products of fibrinogen released by the unknown sample.

REFERENCES:
patent: 3639558 (1972-02-01), Csizmas et al.
patent: 3778352 (1973-12-01), Bishop et al.
Genton et al., "Assay of Plasma Thrombolytic Activity with Fluorescein-Labelled Clots," J. Lab. & Clin. Med., 1964, pp. 313-320.
Alkjaersig et al., "The Mechanism of Clot Dissolution by Plasmin," J. Of Clinical Investigation 38, (1959), pp. 1086-1095.
Unkeless et al., "An Enzymatic Function Associated with Transformation of Fibroblasts by Oncogenic Viruses," J. of Experimental Medicine 137, (1973), pp. 85-111.

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