Process for producing an insulin precursor

Details Process for producing an insulin precursor Process for producing an insulin precursor

1982-02-16

1984-02-07

Waddell, Frederick E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C10352, C07G 700

Patent

active

044302665

ABSTRACT:
A proinsulin-like disulfide insulin precursor is produced from its corresponding linear chain S-sulfonate insulin precursor by reacting the S-sulfonate with a mercaptan in an amount which provides from about 1 to about 5 --SH moieties per --SSO.sub.3.sup.- moiety in an aqueous medium at a pH of from about 7 to about 11.5 and at an S-sulfonate concentration of up to about 10 mg. per ml. of aqueous medium.

REFERENCES:
patent: 3847893 (1974-11-01), Brandenburg et al.
Dixon et al.--Nature, vol. 188, (1960), pp. 721-724.
Steiner et al.--Biochemistry, vol. 60, 1968, pp. 623-629.
Diabetes 13, (1964), pp. 339-347.
Biochemistry, vol. 55, 1966, pp. 1455-1461.

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