Penicillin-polyvinyl alcohol conjugate and process of preparatio

Details Penicillin-polyvinyl alcohol conjugate and process of preparatio Penicillin-polyvinyl alcohol conjugate and process of preparatio

1981-10-19

1984-02-07

Fagelson, Anne P.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424 9, 424 78, 424271, C07D49900, A61K 3143, A61K 39385

Patent

active

044302606

ABSTRACT:
This invention relates to tolerogenic conjugates, suitable for use in suppressing the formation of reaginic antibodies in a host, of haptenic determinants, in particular the benzylpenicilloyl (BPO) group and 2,4-dinitrophenyl (DNP) group, with water-soluble, nonimmunogenic polymers, i.e. polyvinyl alcohols (PVA). The invention also comprises a method for the preparation of the conjugate and a method of suppressing the formation of these antibodies in a mammal sensitive to penicillin.

REFERENCES:
patent: 2155658 (1939-04-01), Herrmann
patent: 3619371 (1971-11-01), Crook
patent: 4261978 (1981-04-01), Lee
patent: 4296097 (1981-10-01), Lee
Sehon, J. Allergy Clin. Immunol., vol. 61, Mar. 1978, p. 179, Ab. No. 167.
Chiorazzi, Fed. Proc., vol. 35, No. 3, 1976, Ab. No. 1258.
Chiller, Fed. Proc., vol. 35, 1976, Ab. No. 1259.
Pah, Fed. Proc. vol. 35, 1976 Ab. No. 1255.

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