Process for optical resolution of (+)-cis-4-aminocyclopent-2-en-

Details Process for optical resolution of (+)-cis-4-aminocyclopent-2-en- Process for optical resolution of (+)-cis-4-aminocyclopent-2-en-

1993-09-29

1994-12-06

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C07B 5500

Patent

active

053712820

ABSTRACT:
In optical resolution of an optically inactive (.+-.)-cis-4-aminocyclopent-2-en-1-carboxylic acid derivative into its (+)-derivative and (-)-derivative, the (.+-.)-cis-4-aminocyclopent-2-en-l-carboxylic acid derivative is allowed to react with an optically active cis-2-(arylalkylamino)cyclohexanemethanol or optically active .alpha.-alkylbenzylamine serving as an optically resolving agent, to form diastereomer salts corresponding to the (+)-cis-4-aminocyclopent-2-en-1-carboxylic acid derivative and the (-)-cis-4-aminocyclopent-2-en-1-carboxylic acid derivative.

REFERENCES:
patent: 4845272 (1989-07-01), Nohira et al.
patent: 4904822 (1990-02-01), Nohira et al.
patent: 5066826 (1991-11-01), Nohira et al.
patent: 5235095 (1993-08-01), Kadkhodayan
patent: 5235101 (1993-08-01), Patil et al.
European Journal of Medicinal Chemistry, vol. 24, No. 4, 1989, pp. 415-420, M. Ikbal, "Synthese des Deux Enantiomeres de l'Analogue Carbocyclique du Nicotamide Ribose et Evaluation de Leurs Proprietes Biologiques".
Journal of Chem. Soc., Chem. Commun., 1990, pp. 1120-1121, Steven J. C. Taylor, et al., "Chemoenzymatic Synthesis of (-)-Carbovir Utilizing a Whole Cell Catalysed Resolution of 2-Azabicyclo[2.2.1]hept-5-en-3-one".
Journal of Chem. Soc. Perkins Trans. 1, 1991, pp. 2479-2484, Martin F. Jones, et al., "Total Synthesis of (-)-Carbovir".
Journal of Chem. Soc. Perkins Trans. 1, 1991, pp. 2605-2607, Stanley M. Roberts, et al., "Enzymatic Resolution of cis- and trans-4-Hydroxycyclopent-2-Enylmethanol Derivatives and a Novel Preparation of Carbocyclic 2',3'-Dideoxydidehydronucleosides and Aristeromycin".
Journal of Chem. Soc. Perkin Trans. 1, 1992, pp. 589-592, Chris T. Evans, et al., "Potential Use of Carbocyclic Nucleosides for the Treatment of AIDS: Chemo-Enzymatic Synthesis of the Enantiomers of Carbovir".

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