Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 15 to 23 amino acid residues in defined sequence
Patent
1993-09-13
1997-06-17
Russel, Jeffrey E.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
15 to 23 amino acid residues in defined sequence
514 12, 514 14, 514 15, 514 16, 514 17, 514 21, 530327, 530328, 530329, 530330, 530350, A61K 3804, A61K 3816, C07K 14005, C07K 14435
Patent
active
056398565
ABSTRACT:
A novel class of proteins, semaphorins, nucleic acids encoding semaphorins, semaphorin peptides, and methods of using semaphorins and semaphorin-encoding nucleic acids are disclosed. Semaphorin peptides and receptor agonists and antagonists provide potent modulators of nerve cell growth and regeneration. The invention provides pharmaceutical compositions, methods for screening chemical libraries for regulators of cell growth/differentiation; semaphorin gene-derived nucleic acids for use in genetic mapping, as probes for related genes, and as diagnostic reagents for genetic neurological disease; specific cellular and animal systems for the development of neurological disease therapy.
REFERENCES:
patent: 5416197 (1995-05-01), Raper et al.
Hames et al, Nucleic acid hybridisation, a practical approach, published 1985 by IRL Press (Oxford), pp. 81, 82, 93-95.
J. Gen. Virol., vol. 73, issued Nov. 1992, Aguado et al, "Nucleotide sequence of 21.8 kbp . . . ", pp. 2887-2902.
J. Gen. Virol., vol. 72, issued 1991, Smith et al, "Nucleotide sequence of 42 kbp of vaccinia . . . ", pp. 1349-1376.
Goodman and Shatz, "Developmental Mechanisms that Generate Precise Patterns of Neuronal Connectivity", Cell, vol. 72/Neuron, vol. 10 (Suppl.), 77-98 (1993).
Raper, "Repulsive Cues in Axonal Guidance", an abstract presented at the GIBCO-BRL Symposium on Genes and Development/Function of Brain on Jul. 26, 1993.
Kolodkin et al., "Fasciclin IV: Sequence, Expression, and Function during Growth Cone Guidance in the Grasshopper Embryo", Neuron, 9:831-845 (1992).
Luo et al., "Collapsin: A Protein in Brain that Induces the Collapse and Paralysis of Neuronal Growth Cones", Cell, 75:217-227 (1993).
Raper and Kapfhammer, "The Enrichment of a Neuronal Growth Cone Collapsing Activity from Embryonic Chick Brain", Neuron, 2:21-29 (1990).
Schnell and Schwab, "Axonal Regeneration in the Rat Spinal Cord Produced by an Antibody Against Myelin-associated Neurite Growth Inhibitors", Nature, 343:269-272 (1990).
Schwab and Caroni, "Oligodendrocytes and CNS Myelin are Nonpermissive Substrates for Neurite Growth and Fibroblast Spreading in vitro", J. Neuroscience, 8(7):2381-2393 (1988).
Kolodkin et al., Cell, vol. 75 (1993) 1389-1399.
Jessell et al., Principles of Neural Science (3rd edition)(1991) chapter 18.
Saneto et al., Neuro chemistry (Chap. 2) (1987) pp. 27-63.
Patel, Biochem. Soc. Trans. (1989) 17(5) 931.
McMartin, Biochem. Soc. Trans (1989) 17(5) pp. 931-934.
Bundgaard et al., Biochem. Soc. Trans., (1989) 17(5) pp. 947-949.
Bentley David R.
Goodman Corey S.
Kolodkin Alex L.
Matthes David
O'Connor Timothy
Osman Richard Aron
Russel Jeffrey E.
The Regents of the University of California
LandOfFree
Semaphorin gene family does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Semaphorin gene family, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Semaphorin gene family will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2158735