Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1977-02-22
1978-05-02
Sneed, Helen M. S.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
542413, 542426, 560121, C07F 722
Patent
active
040874478
ABSTRACT:
The present invention encompasses novel intermediates of the formula: ##STR1## wherein R is phenyl, cyclohexyl or lower alkyl having 1-6 carbon atoms; R' is trialkylsilyl wherein the alkyls have 1-4 carbon atoms, tetrahydropyran-2-yl, or tetrahydrofuran-2-yl; and R" is lower alkyl having 1 to 3 carbon atoms. Compounds of the present invention are useful in synthesizing prostaglandin-like molecules which are active anti-secretory agents.
REFERENCES:
patent: 4038308 (1977-07-01), Strike
Corey, et al., J.A.C.S., 98(1), pp. 222-224 (1976).
Chemical Abstracts, 82 125452y (1975).
Chemical Abstracts, 84 31199k (1976).
J. Organometallic Chem. 109 267,288,328 (1976).
J. Organometallic Chem. 53 30-32 (1973).
Collins Paul W.
Pappo Raphael
G. D. Searle & Co.
McDonnell John J.
Sneed Helen M. S.
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