Guanidinoalkyl glycine .beta.-amino acids useful for inhibiting

Details Guanidinoalkyl glycine .beta.-amino acids useful for inhibiting Guanidinoalkyl glycine .beta.-amino acids useful for inhibiting

1995-01-17

1997-06-17

Criares, Theodore J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514330, 514277, 514247, 514269, 514315, 514432, 514449, 514 20, 514467, 514634, 514317, A61K 31535, A61K 3800, A61K 31155, A61K 3136

Patent

active

056397658

ABSTRACT:
This invention herein relates to a method of inhibiting bone resorption by administering a therapeutically effective amount of a compound having the following formula ##STR1## or a pharmaceutically acceptable salt thereof.

REFERENCES:
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patent: 4952562 (1990-08-01), Klein et al.
patent: 5260277 (1993-11-01), McKenzie
patent: 5403836 (1995-04-01), Blackburn et al.
Fok et al. "Aminopeptidase resistant Arg-Gly-Asp analogs are stable in plasma and inhibit platelet aggregation." Int. J. Peptide Protein Res., 38, 124-130 (1991).
Greenspoon et al. "Structural Analysis of Integrin-Mediated Cell Functions by Novel Nonpeptide Surrogates of the Arg-Gly-Asp Sequence." Biochemistry, 32, 1001-1008 (1993).
McDowell et al. "From Peptide to Non-Peptide. The Elucidation of a Bioactive Conformation of the Arg-Gly-Asp Acid Recognition Sequence." J. Am. Chem. Soc., 116, 5069-5076 (1994).

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