Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxyp

Details Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxyp Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxyp

1990-03-22

1991-02-12

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549323, C07D30720

Patent

active

049925628

ABSTRACT:
A series of novel polypeptide derivatives, containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues, which are useful for inhibiting the angiotensinogen-cleaving action of the enzyme renin. Particularly valuable precursors for many of these compounds are certain other 5-amino-2,5-disubstituted-4-hydroxypentanoic acid derivatives.

REFERENCES:
patent: 4424207 (1984-01-01), Szelke et al.
patent: 4478826 (1984-10-01), Veber et al.
patent: 4613676 (1986-09-01), Fuhrer et al.
patent: 4661473 (1987-04-01), Boger et al.
patent: 4898977 (1990-02-01), Herold et al.
Rich, J. Med. Chem., 28, 263-273 (1985).
Holladay et al., Tetrahedron Letters, 24, 4401-4404 (1983).
Evans et al., J. Org. Chem., 50, 4615-4625 (1985).
Szelke et al., Proc. Am. Pept. Symp. (8th), 1983, 579-582.

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