Process for the preparation of pure thiophene derivatives

Details Process for the preparation of pure thiophene derivatives Process for the preparation of pure thiophene derivatives

1992-11-30

1994-12-06

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549 70, 549 71, 549 80, C07D33322, C07D33328, C07D33338, C07D33308

Patent

active

053712404

ABSTRACT:
3-substituted thiophene compounds contaminating the analogous 2-substituted thiophene compounds, e.g. 3-acetylthiophene contaminating 2-acetyl thiophene, are removed by a selective electrophilic substitution process, e.g. bromination, followed by fractional distillation. It has been found that electrophilic substitution as exemplified by bromination is highly selective towards the 3-substituted thiophenes, yielding compounds of significantly higher molecular weights for separation purposes, to give high purity 2-substituted thiophene compounds.

REFERENCES:
patent: 2581009 (1952-01-01), Emerson et al.
patent: 2714111 (1955-07-01), Herman
J. March, "Advanced Organic Chemistry," p. 17 3rd ed., John Wiley & Sons, New York (1985).
Synthetic Communications, 11(1), 29-34 (1981) "Bromination of Some Heteroaromatic Acyl Compounds With Aqueous Bomine/Sodium Acetate".

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