Process for cephalexin hydrochloride alcoholates

Details Process for cephalexin hydrochloride alcoholates Process for cephalexin hydrochloride alcoholates

1985-06-03

1988-10-04

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540228, 540220, C07D50122, A61K 31545

Patent

active

047757515

ABSTRACT:
The crystalline ethanol or methanol solvates of cephalexin hydrochloride are isolated in high yield from solutions of cephalexin hydrochloride in substantially anhydrous ethanol or methanol, respectively, by adding miscible C.sub.5 -C.sub.6 alkanes after initiating solvate crystallization. Ethanol or methanol solutions of cephalexin hydrochloride can be prepared by adding gaseous HCl to the respective alcohol slurries of cephalexin monohydrate or the novel crystalline ethanolate or desolvated ethanolate. Alternatively, the cephalexin bis-DMF solvate-derived cephalexin hydrochloride isopropanolate can be used to prepare the crystalline hydrochloride monohydrate in accordance with the disclosed improved method.

REFERENCES:
patent: 3507861 (1970-04-01), Morin et al.
patent: 3531481 (1970-09-01), Pfeiffer
patent: 3655656 (1972-04-01), Heyningen
patent: 3781282 (1973-12-01), Garbrecht
patent: 4600773 (1986-07-01), Engel et al.
Pfeiffer, Yang, Tucker, Journal of Pharmaceutical Sciences, vol. 59, No. 12, Dec. 1970, "Crystal Pseudopolymorphism of Cephaloglycin and Cephalexin".

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