Class I MHC modulation of surface receptor activity

Details Class I MHC modulation of surface receptor activity Class I MHC modulation of surface receptor activity

1993-08-12

1997-06-17

Cunningham, Thomas M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Amino acid sequence disclosed in whole or in part; or...

514 2, 514 12, 514 16, 530300, 530324, 530328, 530868, A61K 3800, C07K 1474

Patent

active

056394586

ABSTRACT:
Methods and compositions are provided for regulating surface membrane receptor responses, where the surface membrane receptor is a glucose transporter, by modulating interaction between MHC Class I antigen and the surface membrane receptor. Various techniques may be employed for enhancing or reducing the interaction between the MHC Class I antigen and surface membrane receptor (e.g., enhancing surface expression of the MHC Class I antigen or employing agents which affect interaction between MHC Class I antigen and surface receptors). The aggregative characteristics of oligopeptides which act as agents in affecting interaction between MHC Class I antigen and surface receptors may be employed in a screening assay for determining drugs which affect interaction between Class I antigen and surface receptors. Active peptide aggregative characteristics may also be employed in a method of administration of effectors of surface receptor response modulation.

REFERENCES:
patent: 5385888 (1995-01-01), Goodenow
patent: 5516642 (1996-05-01), Mapelli
Stagsted, J., et al., Cell 62:297-307 (Jul. 27, 1990), "Regulation of Insulin Receptor Functions by a Peptide Derived From a Major Histocompatibility Complex Class I Antigen".

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