Sulfur-substituted diphenyl ethers having antiviral activity

Details Sulfur-substituted diphenyl ethers having antiviral activity Sulfur-substituted diphenyl ethers having antiviral activity

1980-06-12

1982-09-14

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

424337, 564430, 568 29, 568 31, 568 33, 568 36, 568 37, 568 43, 568 44, 568 47, A61K 31135, A61K 3110, C07C 43263

Patent

active

043495680

ABSTRACT:
Novel compounds exhibiting antiviral activity are disclosed, such compounds are represented by the formula: ##STR1## wherein m represents the integer 0, 1 or 2; R represents trihalomethyl, alkyl or phenyl; R.sub.1 represents hydrogen, bromo, chloro, fluoro, cyano, nitro, amino, alkyl, alkoxy or trifluoromethyl; R.sub.2 represents hydroxyl, bromo, chloro, fluoro, cyano, acetyl, benzoyl, substituted benzoyl, alkyl, alkoxy, substituted alkoxy, benzyl, substituted benzyl, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylaminosulfonyl, dialkylaminosulfonyl, or the radical --O(CH.sub.2).sub.n R.sub.4 wherein n represents the integer 1, 2 or 3 and R.sub.4 represents cyano or dialkylamino; R.sub.3 represents hydrogen, hydroxyl, bromo, chloro, fluoro, cyano, acetyl, benzoyl, substituted benzoyl, alkyl, alkoxy, substituted alkoxy, benzyl, substituted benzyl, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylaminosulfonyl, dialkylaminosulfonyl, or the radical --O(CH.sub.2).sub.n R.sub.4 wherein n represents the integer 1, 2 or 3; and R.sub.4 represents cyano or dialkylamino; or alternatively R.sub.2 and R.sub.3 taken together represent the radical --O--C(X).sub.2 --O-- wherein X represents hydrogen, bromo, chloro or fluoro.
Methods of using the above-noted compounds and structurally related compounds to employ their antiviral activity are also disclosed as well as pharmaceutically-acceptable compositions.

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Chem. Abstracts 67:116462q (1967).
Abstract of Swiss Pat. No. 8426 (7/07/77).

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