Delivery of biologically active molecules using cells contained

Details Delivery of biologically active molecules using cells contained Delivery of biologically active molecules using cells contained

1995-05-25

1997-06-17

Ziska, Suzanne E.

Surgery

Controlled release therapeutic device or system

Implanted dynamic device or system

424422, 424424, 424 931, 424 932, 4351723, 4352402, A61K 922, C12N 1500, C12N 500, A01N 6300

Patent

active

056392753

ABSTRACT:
This invention provides improved devices and methods for long-term, stable expression of a biologically active molecule using a biocompatible capsule containing genetically engineered cells for the effective delivery of biologically active molecules to effect or enhance a biological function within a mammalian host. The novel capsules of this invention are biocompatible and are easily retrievable. This invention specifically provides improved methods and compositions which utilize cells transfected with recombinant DNA molecules comprising DNA sequences coding for biologically active molecules operatively linked to promoters that are not subject to down regulation in vivo upon implantation into a mammalian host. Furthermore, the methods of this invention allow for the long-term, stable and efficacious delivery of biologically active molecules from living cells to specific sites within a given mammal. In addition, this invention provides a general means for maintaining, for extended periods of time, the in vivo expression of transgenes.

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