Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1993-04-30
1994-12-06
Draper, Garnette D.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
435 691, 530303, C07K 1300
Patent
active
053711890
ABSTRACT:
The present invention relates to a purified monocyte-derived insulin receptor regulatory factor, which has the biological activity of reducing insulin receptor binding on T-lymphocytes. Additionally, the invention relates to a nucleic acid that codes for the monocyte-derived insulin receptor regulatory factor, a recombinant protein produced therefrom, and an antibody to the factor. The present invention also relates to a method of reducing insulin receptor binding on activated T-lymphocytes, including administration of the protein to a subject.
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Draper Garnette D.
Teng Sally
Vanderbilt University
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