Method for producing indan derivatives

Details Method for producing indan derivatives Method for producing indan derivatives

1988-03-01

1989-05-30

Gray, Bruce D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C07C10352

Patent

active

048353027

ABSTRACT:
A method for producing an indan derivative represented by the formula: ##STR1## by condensing an N-(.alpha.-alkoxycarbonylaralkyl)-.alpha.-amino acid with an N-(indan-2-yl)glycine alkyl or aralkyl ester in the presence of a diphenyl phosphorochloridate, and a method for producing another indan derivative having anti-hypertensive activity by using the above intermediate indan derivative are useful for industrial production of the indan derivative having anti-hypertensive activity.

REFERENCES:
patent: 4532342 (1985-07-01), Hoefle et al.
Chemical and Pharmaceutical Bulletin, Miyake et al., vol. 34, No. 7, 1986, pp. 2852-2858, (English).
Chemische Berichte, Cosmatos et al., vol. 94, No. 10, 1961, pp. 2644-2655, (German).
The Journal of Synthetic Organic Chemistry, Shioiri et al, vol. 31, No. 8, 1973, pp. 666-674, (Japanese).

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